No....... As per Amendment Act 31,2018, it was inserted in Section 34 of CGST Act , One CNT/DNT can be issue against Multiple Invoices & the same get Effective from 1/2/2019 by Notification 2/2019 CT. BUT .... THE PROBLEM IS THE PORTAL HAS NOT BEEN UPDATED AS OF TODAY ACCORDINGLY.
SO you Need to Issue One debit Note for One invoice only.